But are you saving the new command to a folder on your HD? Hitting just OK saves nothing. The command will stay in place only until the next crash (do you get those often?). When you say Palette, do you mean Tool Bar (aka Custom Panel)? When you save a new brush to a Tool Bar, do you save the TB in a folder on a HD? If so, are you saying that when you retrieve the TB the last brush is missing?
Desktop PC W7Pro -64 bit OS; 32.0 GB RAM
Processor: i7-2600 CPU@3.40GHz
NVIDIA Quadro NVS 420; Intuos4 Wacom tablet
4x24 inch monitors ; LAN